Sure. The drone will become less susceptible to wind, more agile and flight time will be a bit longer, but you also "gain" significantly bigger chance to damage on crash (I got one propeller broken in half so far, but there were reports of motors burned or torn out). My advice would be to use the guards for now, while gaining experience.
I damaged my guards, when I got my tello hung up 40 feet up a tree....(ended up spending the night in the tree and at some point it blew out as it was on the ground in the morning waiting for me)...since then I've been flying without guards in and out.....I've had a couple contact crashes inside and so for no damage.
I've only had my tello a couple weeks, so not the most experienced, but at this point il keep guards off.
As others, far more experienced with their Tello's than I have said, guards on indoors, optional off outdoors. Indoors, there is just too much to bump into. Outside, there would be less of the wind affecting flight.. In the end, it is a personal choice. Have fun flying all!